Drug Research Unit in the Department of Clinical Pharmacy, University of California at San Francisco is a clinical pharmacology research facility with the aim to provide state-of-the-art PK/PD studies to inform optimal doses and precise medicines for HIV, malaria, TB, and cancer. Major equipment includes two Sciex LC-MS/MS systems, two Waters UPLC-PDA systems, and an automated liquid handler for sample preparation.
A postdoc research opportunity is available in the Drug Research Unit. The participant will conduct research on quantitative analysis of drugs including, but not limited to, antimalarials and antivirals using liquid chromatography-tandem mass spectrometry (LC-MS/MS) and other analytical methods. A current project (funded by NIH, 1R21 AI153848-01A1) is to explore two-dimensional liquid chromatography tandem mass spectrometry method to quantify unbound antimalarial drugs in human plasma. The participant may also involve in pharmacokinetic data analysis including non-compartment analysis using WinNonlin® or modeling study using NONMEM®. Under the guidance of the mentor/Unit Co-directors, the participant will learn about quantitative analytical method development and validations and complex pharmacokinetic data analysis. The fellow will also be encouraged to take advantage of other training and learning opportunities within the Department of Clinical Pharmacy, the School of Pharmacy, and other related entities at UCSF. The fellow will have opportunities to publish the work in professional journals and/or present data at professional meetings.
PhD in chemistry-related or pharmaceutical sciences. The successful candidate should have strong chemistry awareness and familiarity with analytical chemistry and biochemistry. Working experience with HPLC separation of small/large molecules and data analysis programs (e.g. WinNonlin, Stata, NONMEM) is a plus.
Salary and Benefits
The annual stipend is commensurate with experience and university policy (i.e. $55,632 for newly graduated Ph.D. students in 2022). Benefits include medical and dental insurance. In addition, vacation (24 days a year) and sick leave (12 days a year) are provided.
Equal employment opportunities statement
We welcome applications from all backgrounds. We are committed to providing equal employment opportunities, regardless of ethnicity, nationality, gender, sexual orientation, gender identity, religion, pregnancy, age, disability, or civil partnership, marital or family status. Newly graduated PhD students are encouraged to apply.
Please send your resume and contact information for 3 references to [email protected]. The expected start date for the position is January 2, 2023. The duration is one year with the potential of renewal for a 2nd year if funds are available.