Astellas Pharma is a pharmaceutical company conducting business in more than 70 countries around the world. We are committed to turning innovative science into medical solutions that bring value and hope to patients and their families. Keeping our focus on addressing unmet medical needs and conducting our business with ethics and integrity enables us to improve the health of people throughout the world. For more information on Astellas, please visit our website at www.astellas.com .

Xyphos Biosciences, an affiliate of Astellas Pharma, is developing a novel adoptive cell therapy technology platform and building a pipeline of innovative products. We are a rapidly growing team of research and scientific professionals, passionate about turning science and innovation into medical solutions through our cell therapy technology platform. Through our diversity, scientific knowledge, professional rigor and focus on innovation, we are merging our technology with the Astellas drug development expertise to unlock cures to many therapies. Join our team of committed, enthusiastic professionals devoted to making the most effective, life-saving cell therapy products in the world.

Astellas is announcing a Scientist I, Immuno-Oncology opportunity at their Xyphos site in South San Francisco, CA.

Job Description:

Xyphos Biosciences (South San Francisco, CA) is looking for a motivated and talented Scientist I to join our Research and Discovery group. Our dynamic and highly collaborative team is innovation-focused in order to enhance our universal convertible CAR cellular therapy platform and advance its application to address a number of oncology indications through novel target identification, optimized engagement of convertible CAR-bearing immune cells, and minimization of the effects of immunosuppressive signals. The successful candidate is expected to contribute scientifically to both external collaborations and internal projects to support platform development and to explore its application in solid tumors. This position is expected to be 75% lab-based and there will be opportunities for career growth through cross-functional coordination and communication, building of scientific relationships in our global organization, and the opportunity to participate in the development of candidate drug programs.

Essential Job Responsibilities:

• Understand the biology behind tumor targets in order to inform upon research strategy to optimize engagement of convertible CAR-bearing effector cells including T cells and NK cells

• Actively contribute to scientific discussions through reading of scientific literature, hypothesis formation, and becoming a subject matter expert to maximally support projects and champion their continued progress or drive quickly to go/no-go decisions

• Be able to engage with multiple projects simultaneously, effectively collaborate cross-functionally with colleagues to develop the resources and strategies needed for a project, and deliver experimental results in a timely manner

• Proactively explore, evaluate, and implement cell-based assays to support mechanism of action studies and candidate selection for tumor-targeting biologics

• Aid in the identification of appropriate solid tumor models, contribute to the design of in vitro and in vivo studies, and facilitate their implementation as the project or program requires

• Effectively communicate with team members to efficiently conduct experiments, articulate experimental details and results with other members of the Astellas research organization, and present research findings and recommendations to senior leadership