HOW MIGHT YOU DEFY IMAGINATION?
You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.
Senior Associate Scientist – Cell Based Assays
Live
What you will do
Let’s do this. Let’s change the world. In this vital role you will be a part of the Therapeutic Discovery organization joining the Discovery Technologies department in support of Amgen’s small molecule drug discovery pipeline.
- The development and optimization of novel cell-based assays ensure successful implementation and routine implementation of these assays to support HTS, lead optimization, and mechanism-of-action studies for promising therapeutic targets
- Design and implement laboratory experiments, generate and interpret data supporting the successful development of new assays and test the biological effects of therapeutic agents
- Design, implement, and optimize gene-editing workflows in a manner that enables development and evaluation of cell-based functional assays supporting therapeutic target screening or lead optimization studies
- Learn, apply, and incorporate automation solutions during assay development, assay troubleshooting, mechanism-of-action studies, data analysis, and reporting
- Investigate, identify, develop, and optimize new methods/techniques to generate reliable and reproducible data promptly
- Semi-independently plan and implement experiments, adapt readily to changing project needs and develop sophisticated problem-identification and problem resolution skills
- Maintain proficiency with the latest scientific literature and rationale surrounding drug targets and be an active contributor to the interpretation of results in group discussions
- Show excellent collaboration and communication skills as this role requires an ability to work closely with other scientists in the group and across Amgen
- Adherence to good laboratory conduct, documentation practices, and safety guideline
Win
What we expect of you
We are all different, yet we all use our unique contributions to serve patients. The qualified professional we seek is a bench scientist with these qualifications.
Basic Qualifications:
Master’s degree and 3 years of scientific experience
Or
Bachelor’s degree and 5 years of scientific experience
Preferred Qualifications:
- Ph.D. degree with 1+ years of post-doctoral training or a master’s degree with 4+ years postgraduate experience in cell and/or molecular biology or closely related field
- Experience working as part of a multi-disciplinary team in a biopharmaceutical setting
- Familiarity with assay technologies including luminescence, fluorescence and FRET/BRET with experience in the utilization of lab automation across assay development and screening
- Ability to design and implement gene editing (CRISPR knock out/in) workflows enabling the development of targets specific and disease-relevant cell-based assays
- Track record of developing, implementing, and performing novel cell-based screening assays in (384 and/or 1536 well plates) to support early drug discovery research
- Ability to create and establish priorities, manage work plans, and meet timelines
- Capacity to identify, evaluate, implement, and become proficient in novel laboratory techniques
- A flexible approach with strong interpersonal, communication and problem-solving skills
- Demonstrated initiative, teamwork, collaboration and passion for developing technical expertise across assay development to routine execution
- Strong scientific foundation in the understanding and implementation of a wide range of cell-based assays and readouts (e.g., TR-FRET, BRET, PCA, AlphaLISA, MSD, HCS, luminescence and fluorescence-based reporter and/or label-free assays)
- Broad experience and expertise in molecular reagent generation and cell line engineering using gene editing approaches (CRISPR) as well as development and implementation of novel cellular target engagement, activity, and PPI assays (e.g., immunoassays, second messenger generation, ion flux, reporter, protein stability, PPI (splitNanoLuc, splitFAST, splitβ-gal), gene activation, cellular imaging)
- Experience with cell characterization and analytical techniques such as DNA sequencing, qPCR and protein expression as well as expertise with phenotypic and functional characterization of immortalized or primary cells
- Experience with assay development in RNA therapeutics such as high-throughput RT-qPCR, RNA-FISH, and characterization of in-cell RNA binding
- Established capabilities in setting-up and operation of multimode plate readers (e.g., FLIPR, EnVision, ViewLux, PHERAstar) and automated liquid handlers (e.g., Bravo, Echo, Tempest, BlueWasher) in the development of 384- and/or 1536-well microtiter plate assays
- Familiarity with software and statistical platforms for the analysis of large data sets (e.g., Screener, Spotfire)
Thrive
Some of the vast rewards of working here
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
- Full support and career-development resources to expand your skills, enhance your expertise, and improve your potential along your career journey
- A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
- Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor
Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.com
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.
Apply at: https://careers.amgen.com/job/15120794/senior-associate-scientist-cell-based-assays/
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