Merck & Co., Inc. are seeking an innovative synthetic chemist or bioconjugation chemist to join the company's Exploratory Science Center (MESC) in Cambridge, MA.
The successful candidate will become part of a lab-based, creative and fast-paced team that will discover novel biology and invent impactful technologies targeting oncology, inflammation, cardiovascular, metabolism and neuroscience.
This is a lab-based position and an excellent opportunity for someone seeking scientific and career growth in a multidisciplinary area of drug discovery. Your personal growth and career development will contribute to the success of our team. The candidate will be part of a cross-functional team contributing to the strategic direction of research programs across multiple therapeutic modalities.
Responsibilities include and are not limited to the following:
- Develop and optimize bio-conjugation technologies, synthesize payloads and linkers for conjugation
- Help identify and validate new targets, which may include collaborative engagement with the external scientific community and leadership of early drug discovery projects
- Execute synthetic chemistry across a wide range of chemical modalities
- Act as a leader from the bench, to drive chemistry strategy for various programs
- Leverage advances in chemical synthesis and delivery technologies of complex large molecules to impact multiple ESC programs
- Provide scientific mentoring and technical training of team members as appropriate
- Ensure all laboratory safety protocols are followed
Required Experience:
- Bio-conjugation of payload to antibody or protein scaffolds
- Independent synthetic route design and expertise in the multi-step synthesis
- Strong background in organic synthesis with focus on peptides, carbohydrates or small molecules
- Experience in synthesis of oligonucleotide will be a plus
- Strong publication record and effective written and oral communication skills
Preferred Experience:
- Hands-on experience in bio-analytical techniques such as CE-SDS, Western Blot, SEC, HPLC, DLS, MS-ToF etc.)
- Hands-on experience in molecular cloning, cell culture, protein expression and purification, characterization will be a plus
Education:
- PhD or M.S. in synthetic organic chemistry, chemical biology, macromolecular chemistry or related discipline
- Minimum of 5 + years of industrial experience after M.S. or 0 to 3 years after PhD
Apply at: https://jobs.merck.com/us/en/job/R112589/Senior-Scientist-in-Molecular-Discovery
Organization Details
Please note that these positions are not directly affiliated with the OCPD or UCSF; please visit the employer's website for full details, as they may be subject to change, and contact the employer directly with any questions. The content of the post is solely the responsibility of the employer.