The Raleigh Lab at the University of California San Francisco (UCSF) has 1 available position for a postdoctoral scholar with experience in wet lab techniques, and experience and/or interest in organoid models of brain cancer. Research in the Raleigh lab is focused on understanding the genomic, biochemical, and cellular drivers of tumor heterogeneity and evolution. Our team of basic scientists, bioinformaticians, and clinicians integrate human samples with diverse evolutionary and preclinical models to study cancer predisposition, tumorigenesis, and treatment resistance. In addition to showing how tumors develop and respond to therapy, our studies have elucidated mechanisms through neurofibromatosis tumor suppressor genes, epigenetic regulators, and the Hedgehog pathway that drive developmental patterning and stem cell homeostasis. 

The Raleigh Lab is located at the UCSF Mission Bay Medical Center in the Brain Tumor Center on the 4th floor of the Helen Diller Family Comprehensive Cancer Center Research Building. Dr. Raleigh is a Physician Scientist in the Departments of Radiation Oncology, Neurological Surgery, and Pathology at UCSF. He is the Robert and Ruth Halperin Endowed Chair in Meningioma Research, and the Director of the Preclinical Therapeutics Core in the UCSF Brain Tumor Center. Eighty percent of his time is dedicated to research, and the postdoctoral position that is available is focused on improving understanding of meningioma biology and treatments for patients with meningioma. All prior trainees in the Raleigh Lab have matriculated to successful independent careers in science and/or medicine. 

Highly motivated individuals with doctoral training from broad scientific backgrounds are encouraged to apply. Ideal candidates will possess training in wet lab techniques, and have a drive to improve their experimental, analytic, scientific writing, and leadership skills. Mentorship and collaborative multidisciplinary science are essential in the Raleigh Lab, and candidates should have an aptitude for mentorship of junior lab members. Potential projects include investigations of inter-tumor heterogeneity (PMID: 35534562, 36227281, 29590631), intra-tumor heterogeneity (PMID: 32968068, 32023450, 35759011), predictive biomarkers (PMID: 37944590, 37963810, 38057502), signaling mechanisms (PMID: 30340023, 29202464, 38216572, https://www.researchsquare.com/article/rs-2577844/v1), and cancer stem cells (PMID: 31901251, 36067288, 38742767) using diverse experimental approaches, including functional genomic techniques (PMID: 33476305, 38216587) and spatial genomic techniques (PMID: 38760638).