Pfizer Cancer Immunology Discovery (CID) is within the Oncology division of Pfizer Worldwide Research & Development in La Jolla, CA. CID is dedicated to developing new protein therapeutics to improve human life by redirecting the immune system against cancer. CID researchers apply the latest scientific knowledge and novel approaches to discover truly innovative Immuno-Oncology therapeutics. We are seeking to hire multiple Senior Scientists for the CID Immunosuppression group.

Responsibilities

• Discovery and evaluation of novel mechanisms of tumor resistance to innate and adaptive immunity
• Design and execution of cell based functional and biochemical assays to select candidate molecules for clinical development
• Design and execution of drug mechanism of action studies using in vivo models and ex vivo methods, such as cell sorting, multi-color flow cytometry, immunohistochemistry/immunofluorescence, and primary cell culture and human 3D/organoid/explant assays.
• Communication of research results to team and company

Basic Qualifications

• Ph.D. with 1+ years of experience; or MS with 7+ years of experience, or BS/BA with 10+ years’ experience
• Experience in the fields of immunology, cell biology and/or genetics
• Ability to independently design, plan and execute and interpret experiments
• Ability to manage an independent research program with minimal supervision
• Expertise in standard immunologic techniques
• Expertise in qRT-PCR, ELISA, MSD, ELISPOT, Nano string and cytotoxic assays
• Experience in CRISPR technology, lentiviral transduction, data mining (TCGA, single cell RNA sequencing, cBioportal)
• Experience working with small molecules inhibitors and biologics for tumor immunotherapy
• Immune phenotyping tumor associated immune cells from primary human tumor samples by flow cytometry and other high dimensional approaches including CyTOF

Preferred Qualifications

• Technical expertise with immune cell-based functional assays (e.g. activation, differentiation, proliferation, and suppression assays by using monocyte/ macrophages, T-cells, or dendritic cells, tumor-stroma immune cell co-culture assays)
• Expertise in 3D spheroid and other complex ex vivo assays that mimic human tumor microenvironment
• Experience with human PBMC and mammalian cell culture
• Excellent organization and planning skills, the ability to work in a fast-paced environment independently or as part of a team, good verbal and written communication, and strong motivation with a dedicated work ethic

Physical or Mental Requirements

• Standing, sitting, bending, lifting, walking in a laboratory or vivarium setting.
• Use of Personal Protective Equipment (PPE) in a BSL-2 laboratory; additional PPE requirements when working in vivarium barrier suites.
• Standard business office conditions; sitting, standing as appropriate
• Infrequent travel

Other Job Details

• Eligible for Relocation Package
• Eligible for Employee Referral Bonus
• #LI-PFE

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EEO & Employment Eligibility

Pfizer is committed to equal opportunity in the terms and conditions of employment for all employees and job applicants without regard to race, color, religion, sex, sexual orientation, age, gender identity or gender expression, national origin, disability or veteran status.  Pfizer also complies with all applicable national, state and local laws governing nondiscrimination in employment as well as work authorization and employment eligibility verification requirements of the Immigration and Nationality Act and IRCA.  Pfizer is an E-Verify employer.