HOW MIGHT YOU DEFY IMAGINATION?
You’ve earned your degree. How will you use that achievement to reach your goals? Do more with the knowledge you’ve worked hard to acquire and the passion you already have. At Amgen, our shared mission—to serve patients—drives all that we do. It is key to our becoming one of the world’s leading biotechnology companies, reaching over 10 million patients worldwide. Become the professional you are meant to be in this meaningful role.
Senior Associate Scientist – Enzymology/Biochemistry/Biophysics
Live
What you will do
Let’s do this. Let’s change the world. Amgen is seeking a dedicated and motivated individual with expertise in enzymology and biochemical & biophysical assay development to join the Bioassay & Profiling group to support small molecule drug discovery programs within the Discovery Technologies department in our South San Francisco research site. The successful candidate should possess strong technical expertise & exceptional hands-on laboratory skills, have excellent written and oral communication skills, enjoy working in a fast-paced multi-functional team environment, and keep current with field of expertise, including literature and technology development.
Key Responsibilities:
- Contribute to assay strategies and apply a variety of scientific principles and concepts to the assay design, assay development and troubleshooting in support of the drug discovery process.
- Develop and implement biochemical assays and convert into high-throughput screening (HTS) format to enable HTS campaign and meet project goals.
- Apply biochemical and biophysical assay techniques to develop and perform potency, kinetic and mechanistic assays for hits validation, compound-target engagement, and SAR study.
- Advance biochemical/biophysical assay screening capabilities and evaluate new assay technologies and experimental approaches using scientific theory and technical literature.
- Represent the department in multi-disciplinary project teams to present research results and provide scientific and technical support.
- Collaborate with internal cross-functional teams and external partners to enable project progression
Win
What we expect of you
We are all different, yet we all use our contributions to serve patients. The skilled professional we seek is a dedicated scientist with these qualifications.
Basic Qualifications
Master's degree and 3 years of scientific experience
Or
Bachelor’s degree and 5 years of scientific experience
Preferred Qualifications
- PhD in biophysics, biochemistry, molecular biology, or a related field and 3 years of related scientific experience in academia or industry
- Expertise in enzymology, ligand binding kinetics, and mechanism-of-action studies.
- A deep and broad understanding of the development, validation & implementation of a wide array of binding & functional activity-based assays such as AlphaScreen, TR-FRET, FP, etc.
- Experience with biophysical techniques and instruments used to characterize ligand binding such as Microscale Thermophoresis (MST), Differential Scanning Fluorimetry (DSF), Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), etc.
- Experience with microplate readers such as PerkinElmer Envision and automated liquid handling systems including Multidrop, acoustic dispensers, and digital dispensers.
- Expertise in handling, analyzing and visualizing assay data sets and proficient in software platform such as GraphPad Prism.
- Drug discovery research experience in diverse target classes is a plus but not required.
- Meticulous and analytical with excellent problem-solving skills.
- Excellent organizational, interpersonal and communication skills, along with the ability to work in a flexible team-oriented environment.
Thrive
Some of the vast rewards of working here
As we work to develop treatments that take care of others, we also work to care for our teammates’ professional and personal growth and well-being.
- Full support and career-development resources to expand your skills, enhance your expertise, and increase your potential along your career journey
- A diverse and inclusive community of belonging, where teammates are empowered to bring ideas to the table and act
- Generous Total Rewards Plan—comprising health, finance and wealth, work/life balance, and career benefits—with compensation and benefits rated above 4 stars (out of 5) on Glassdoor
Apply now
for a career that defies imagination
Objects in your future are closer than they appear. Join us.
careers.amgen.com
Amgen is an Equal Opportunity employer and will consider you without regard to your race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, or disability status.
We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.
Amgen requires all staff in the United States and Puerto Rico to be vaccinated from COVID 19 as a condition of employment. In accordance with applicable law, Amgen will provide reasonable accommodations to staff members who qualify on the basis of a medical reason or a sincerely held religious belief, practice, or observance. Such accommodation may not pose an undue hardship to Amgen, its operations, or its staff.
Apply to: https://careers.amgen.com/job/15131373/senior-associate-scientist-enzymology-biochemistry-biophysics/
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