Role/Responsibilities:

• Design and implementation of PDX, CDX and GEMM tumor models in mice for multiple tumor indications in rental vivarium space (Explora Biolabs, SSF, CA)
• Acquire and scale (≤ one rack for a team of 2 experienced in vivo scientists) the above models into robust platform(s) capable of interrogating CAR-T therapeutic efficacy in vivo
• Perform early research through asset identification and development, ultimately leading to  preclinical/IND data packages for novel, engineered cell therapies
• Work as part of a small in vivo team (~2 people initially) within a larger multidisciplinary team (10 people as of job posting) to identify, procure, design and execute all in vivo experiments 
• Acquire, analyze and effectively communicate data to the team
• Responsible for helping to scope and achieve in vivo milestones, maintaining high scientific rigor as well as teaching and mentoring current and future scientists

Required Skills:

• Proficient in handling small laboratory animals (i.e. mice and rats) including tagging, weighing, and taking caliper measurements
• Able to prepare formulations of CAR-T cells, administer CARs and/or drug compounds and biological test articles via various routes (IV, PO, IP, SQ), collect blood, administer anesthesia, perform euthanasia, and harvest/process various tissue samples for analysis
• Experience operating in vivo optical imaging instruments (e.g. IVIS)
• Familiarity with a variety of in vivo immuno-oncology models (i.e. xenograft, syngeneic, PDX)
• Familiarity with IACUC protocols and regulations involved with in vivo work
• Understanding and comprehension of techniques, nomenclature, equipment, etc. as they relate specifically to job performance function in the laboratory animal research environment
• Ability to organize, communicate, and present complex datasets to key stakeholders

Preferred Additional Skills:

• Ability to perform aseptic cell culture of primary and established immune and tumor cell lines, run immunoassays (e.g., ELISA, MSD, Luminex), and analyze cells by flow cytometry
• Proficiency in the standard office suite (e.g. Google Docs, Keynote, Excel) as well as specialized statistics (e.g. Graphpad Prism) and analysis software (e.g. FlowJo, FCS Express)