Scientist, Aging Metabolism

Location: 
1130 Veterans Blvd
South San Francisco, CA 94080
United States
Job Posted Date: 
November 22, 2024
Opportunities: 
Full-time Positions
Population: 
Life Sciences

Position Description:

Calico is seeking a highly motivated scientist to join and lead discovery research projects in the metabolism of aging group. Specifically, we are interested in applicants with a long-term interest in understanding metabolic mechanisms in normal physiology and pathology, including cancer. We seek expertise in combining cutting-edge molecular and biochemical techniques, including transcriptomics and metabolomics, with in vitro and in vivo models to uncover metabolic interactions in health and disease. Join our collaborative, cross-functional environment at the forefront of aging research, work alongside world-class technology labs, and lead ambitious research projects that could transform our understanding of aging.

Responsibilities: 

  • Perform basic research to determine metabolic mechanisms underlying aging process 
  • Develop approaches to evaluate metabolic interactions between specific cell types during aging 
  • Publish papers and present findings both internally and at scientific conferences
Job Requirements: 

Position Requirements:

  • PhD or MD/PhD in cell/molecular biology, biochemistry or a related field with 0-5 years of postdoctoral and/or industry experience
  • Experience working with animal models to study human disease and/or aging
  • Deep knowledge of cellular and organismal metabolism and physiology
  • Strong working knowledge of genetics, cell biology and molecular genetics
  • Detail-oriented, organized and driven
  • A track record of strong research productivity
  • Strong teamwork and communication skills
  • Flexible, able to respond quickly to shifting priorities and able to multitask
  • Must be willing to work onsite five days per week

Nice to Have:

  • Experience with mass spectrometry to measure metabolites and/or lipids and/or proteins
  • Experience using stable isotope labeling to understand metabolic fluxes in vitro and/or in vivo
  • Experience with integrating multiomics data
  • Expertise in immune biology and immune cell cultures
  • Competence with mammalian tissue culture, in vitro gene editing techniques (CRISPR/Cas9, viral transduction) and basic molecular biology methods
  • Familiarity with R or Python for data analysis and visualization

The estimated base salary range for this role is $127,000 - $155,000. Actual pay will be based on a number of factors including experience and qualifications. This position is also eligible for two annual cash bonuses.

Location: 
San Francisco
Greater Bay Area
Peninsula
California