Brief Description of SyntheX
SyntheX is using synthetic biology and genetic engineering to discover first in class therapeutics to modulate protein interactions. We’ve built two platforms based on our proprietary selection technology, ToRPPIDO and ToRNeDO, to address key outstanding problems in drug discovery. ToRPPIDO allows us to efficiently discover compounds that can disrupt specific protein-protein interactions (PPIs) within cells. ToRNeDO enables the inverse and allows us to discover molecular glues that bring two proteins together – more specifically, an E3 ubiquitin ligase of our choice and a neosubstrate of interest, to enable targeted protein degradation.
Our current focus is on oncology, where we've generated a differentiated pre-clinical pipeline exploiting unique mechanisms of action uncovered by our platforms.
We are a fast growing startup located in the Mission Bay neighborhood of San Francisco. Additional information can be found on www.synthexlabs.com. Submit CV and cover letter to [email protected].
Job Summary
SyntheX is looking for a talented, enthusiastic, and highly motivated yeast geneticist with a strong background in synthetic biology & strain engineering to continue to evolve and operate our drug discovery platforms.
Requirements
- Ph.D. or MSc, Molecular Biology, Microbiology, Bioengineering, Biochemistry, Genetics, Synthetic Biology or closely related field
- 5+ years of lab experience in demanding, analytical work environment is preferred
- 2+ years of biotech start-up or industry experience is highly valued, but not a prerequisite
Skills and Experience
- Demonstrated ability to design, construct, and engineer genetic or metabolic pathways.
- Experience working with S. cerevisiae and E. coli is required; additional experience with other microorganisms is a plus.
- Hands on experience with synthetic biology and strain engineering techniques such as PCR, Gibson Assembly, restriction digestion, ligation, and homologous recombination.
- Design and implement molecular and synthetic biology workflows for the construction of plasmids, strains, and enzymes to facilitate strain engineering efforts.
- Experience with protein expression, purification, and enzymatic assays is plus.
- Experience with protein-protein interaction assays is a plus.
- Experience with protein degradation is a plus.
- Excellent time management skills, effective with multitasking, and an adept ability to improvise work plans while maintaining efficiency.
- Demonstrated communication and collaboration skills.
- Demonstrates strong motivation, rigorous attention to detail, excellent documentation, and ability to think independently and fully integrate into a high achieving team environment.
- Ability to work independently and effectively on multiple programs in a dynamic environment.
- Curiosity and a passion for science!
Responsibilities
- As a key team member, the candidate will be involved in designing, optimizing, establishing, and executing a wide-range of genetic and cell-based assays to support our discovery programs.
- Thinking critically and creatively to generate and execute ideas to positively impact project goals.
- Assist with the expansion of the group’s capabilities by exploring new technologies and strategies to improve experimental throughput and support automation efforts.
- Recommend alternatives, research new methods and techniques and proactively seeks out potential solutions to problems.
- Coordinate with external collaborators, partners, and vendors to ensure smooth workflow between all stakeholders.
- Mentor and guide junior Research Associates as needed.
- Independently write technical reports and technical presentations within the area of expertise.
- Provide regular project updates in team meetings.
- Strong scientific and laboratory skills with a keen eye for detail and a passion for science, innovation, problem solving, and learning.
Development Opportunities
This role offers a unique opportunity to be part of growing a company. It offers significant exposure to new scientific research and development. A successful candidate will have the opportunity for career progression and professional growth as the company grows. It is an opportunity to work with a small, dedicated, and diverse professional team working towards the goal of expanding the drug discovery toolkit by solving difficult outstanding problems to advance novel therapies to patients.
The position offers a competitive salary, equity, 401K, parental leave, and full medical coverage. When feasible, we provide visa assistance for qualified candidates.
Please send a cover letter and CV to [email protected]
Organization Details
By performing intracellular selections, we can rapidly and efficiently discover compounds that can modulate protein-protein interactions for PPI disruption or to achieve targeted protein degradation.
Our focus is on oncology, where our technologies have generated a best in class pipeline targeting difficult proteins and exploiting unique mechanisms of action.
We're a rapidly growing company, scaling our team with stellar scientists to support additional platform operations, further our internal pipeline, and execute on pharma collaborations.