Northern California Institute for Research and Education (NCIRE) is the leading nonprofit research institute in the United States devoted to advancing Veterans health research. NCIRE is part of one of the world’s most dedicated and successful Veterans care communities, pioneering new treatments and understandings of military medicine and care. Along with our partners at the San Francisco VA Health Care System and the University of California, San Francisco, we are working to discover and develop effective, safe, and practical treatments for military injuries and diseases affecting Veterans. Through new technologies, novel scientific insights, and international clinical collaborations, we strive to set a new standard of health care research for Veterans and military personnel.        

Position Definition:

The incumbent will train under the Principal Investigator in the general area of the control of bone mass by G protein signaling in osteoblasts.  He/she will be conducting research experiments to evaluate the role of specific Wnt genes in mediating the skeletal abnormalities in a mouse model of skeletal fibrous dysplasia.  He/she will also receive guidance from the Principal Investigator in manuscript and grant writing skills to facilitate development as an independent research scientist.

Essential Functions:

• Carry out skeletal phenotyping of mice including micro-CT, bone histology, and analysis of gene expression
• Perform spatial omics to assess how alterations in Wnt genes affects the expression of genes and proteins in specific bone cell populations
• Conduct experiments using primary cell culture of bone marrow osteoprogenitors
• Write drafts of manuscripts describing experimental results
• Prepare various chemicals for experimental use
• Perform statistical analysis of experimental results and findings
• Perform supply ordering/maintenance and equipment maintenance; perform additional general laboratory management duties as assigned
• Perform other related duties as assigned

Job Requirements:

• Completion of a doctoral program in biomedical sciences
• Prior experience in a laboratory environment and basic knowledge of procedures used in biochemistry/molecular biology research
• Strong oral/written communication and organizational skills
• Ability to accurately follow experimental protocols
• Ability to manage multiple projects, tasks and priorities to achieve desired goals

The base salary range for this position is $64,480.00-$79,639.96 per year. The base salary actually offered to a successful candidate will take into account various relevant and non-discriminatory business factors including, without limitation, the candidate’s geographic location, job-related experience, knowledge, and skills, and education, as well as internal equity considerations. A successful candidate may also be eligible to earn additional compensation including bonuses.