Principal Scientist, Lead Discovery

1400 Sierra Point Parkway
Brisbane, CA 94005
United States
Job Posted Date: 
May 31, 2023
Full-time Positions
Life Sciences

We are seeking a highly motivated and innovative Lead Discovery Scientist to join our Discovery team. In this role, you will play a key part in leading the design and implementation of in vitro biochemical and biophysical assays for our expanding portfolio targets. You will provide a broad scientific and technical expertise in assay development, high throughput screening, lead identification assays and data analysis. You will work as part of a multi-disciplinary project team in executing drug discovery projects from target validation and screening through candidate identification.


Key responsibilities include:

  • Together with the key stakeholders, design, develop and execute diverse biochemical and biophysical assays for small molecule discovery
  • Implement small molecule discovery campaigns using cutting edge screening technologies to identify small molecules that modulate protein-protein interactions (HTS, DEL, AS-MS, etc.)
  • Develop and execute of biochemical and biophysical assays for measuring protein-protein, protein-ligand interactions, or enzymatic activity (TR-FRET, FP, SPR, DSF, ITC, etc.)
  • Technical and scientific leader in identifying and enabling state-of-the art technologies and robust workflows to accelerate lead identification
  • Investigate mechanism(s)-of -action, protein-protein or small molecule-protein complex characterization using biophysical and structural approaches
  • Cross-functional project team collaboration, including providing structure-activity relationship for small molecules in on-going compound optimization
  • Presentation of research findings to senior management and other stakeholders within and outside the company

The expected salary range for this position is $145,000 - $185,000.  Actual pay will be determined based on experience, qualifications, and other job-related factors 

Interline offers a robust benefits package to our eligible employees including competitive medical, dental, and vision insurance, equity incentive plan, 401(k) program and a generous holiday and PTO policy

All qualified applicants will receive consideration for employment without regard to race, sex, color, religion, sexual orientation, gender identity, national origin, protected veteran status, or on the basis of disability


Job Requirements: 


  • Ph.D. in Biochemistry, Biophysics, or related field with 5+ years of post-degree experience in small molecule drug discovery program(s)
  • A deep understanding of protein-protein and small molecule-protein interaction assay design, development and troubleshooting
  • Expertise in biochemical and biophysical assay development (e.g., FP, TR-FRET, DSF, SPR, ITC, etc.)
  • Experience in small molecule hit discovery campaigns (e.g., HTS, DEL, AS-MS, etc.)
  • Experience in assay automation including nanoliter dispensing, liquid handlers, and high throughput platforms
  • Expertise in general biochemical and molecular biology techniques, including protein expression & purification and structural biology is preferred
  • Commitment to the highest quality work with a strong track record of scientific accomplishment (publications, presentations, industry experience)
  • Strong desire to work collaboratively within an innovative team environment
How to Apply:

San Francisco
Greater Bay Area