Our organization received funding and are conducting pre-clinical research in transplant medicine, focusing on genetic engineering techniques to improve organ transplant compatibility and reduce rejection. The intention of the pre-clinical trial is to get the results published in a scientific journal and evaluate implementation in transplant recipients.
We are specifically studying two potential pathways.
- Deactivation of HLA genes in donor organs using CRISPR-Cas9 delivered via lentiviral vectors or electroporation.
- Creating chimeric bone marrow via engineered CD34+ cells.
Experience/Skills:
1.Gene knockout engineering using lentiviral vectors or electroporation and CRISPR-Cas9
2.Engineering CD34+ cells
3.Strong knowledge of the immune system
4.Good Laboratory Practice (GLP) standards with animal models
5.Research design and scientific investigation background
Preferred Experience:
1.Performed research studies
2.Understanding of hematopoetic stem cell chimerism
3.Familiarity with FDA approval processes
4.Post-doctorate or PhD
Send email with resume to [email protected]