Pre-Clinical Research: Engineering CD34+ Hematopoietic Stem Cells

Location: 
3739 Balboa Street #1057
San Francisco, CA 94121
United States
Job Posted Date: 
July 23, 2024
Opportunities: 
Part-time Positions
Postdoc Positions
Volunteer Positions
Population: 
Life Sciences
Medicine

Our organization received funding and are conducting pre-clinical research in transplant medicine, focusing on genetic engineering techniques to improve organ transplant compatibility and reduce rejection. The intention of the pre-clinical trial is to get the results published in a scientific journal and evaluate implementation in transplant recipients.

     We are specifically studying two potential pathways.

  • Deactivation of HLA genes in donor organs using CRISPR-Cas9 delivered via lentiviral vectors or electroporation.
  • Creating chimeric bone marrow via engineered CD34+ cells. 
Job Requirements: 

Experience/Skills:

1.Gene knockout engineering using lentiviral vectors or electroporation and CRISPR-Cas9

2.Engineering CD34+ cells

3.Strong knowledge of the immune system

4.Good Laboratory Practice (GLP) standards with animal models

5.Research design and scientific investigation background

Preferred Experience:

1.Performed research studies

2.Understanding of hematopoetic stem cell chimerism 

3.Familiarity with FDA approval processes

4.Post-doctorate or PhD

How to Apply: 

Send email with resume to  [email protected]

Location: 
San Francisco
Greater Bay Area
Peninsula
California