A postdoctoral fellowship position for a highly motivated scientist is available in Drs.Chen/Bastian laboratory in the Helen Diller Family Cancer Center at the University of California, San Francisco. The project is focused on to study the signaling of mutant G proteins in uveal melanoma. Uveal melanoma is a rare cancer without any curative treatment options. It is genetically characterized by mutations in the Gαq signaling pathways, as our lab has previously reported (Nature: PMID: 19078957; N Engl J Med: PMID: 21083380; Oncogene: PMID: 24141786, Cancer Cell PMID: 28486107; Nature Genetics: PMID: 31253977; Oncogene: PMID: 33262460). The candidate will help elucidate the downstream signaling, identify therapeutic targets, with the goal to identify effective therapeutic strategies, with the supports of grants from the National Cancer Institute, the Department of Defense and the Melanoma Research Alliance.  The candidate will get in depth exposure to cutting edge in-vitro methods including multi-omic approaches and Crispr/Cas9 screens and use newly developed mouse models for in vivo studies.