POSITION SUMMARY

The Ellerby lab at the Buck Institute is seeking a Postdoctoral Scientist to model neurodegenerative diseases- Alzheimer’s , Huntington’s disease or X-Linked Dystonia Parkinsonism - using iPSCs. The successful candidate will have some experience in stem cell biology, neurodegenerative diseases, and use of mouse models of disease. They will have a demonstrated aptitude to be a leading author on peer-reviewed publications, provide innovative solutions to research problems, and can apply for fellowship/scholarship awards.  This work is in collaboration with the Campisi, Melov or Schilling labs.

The Ellerby lab focuses on understanding the fundamental mechanisms that lead to age-related neurodegenerative diseases and identifying new therapeutic targets for these diseases. We are excited to use new technologies to interrogate why these neurological diseases are so abundant as we age and identify small molecule or protein therapeutics for these diseases. Induced pluripotent stem cells (iPSC) derived from patient cells, genomics, proteomics, small molecule screens, single cell analysis, and CRISPR/Cas9 are all technologies applied to deepen our understanding of these diseases and aging.

KEY RESPONSIBILITIES

• Participate in innovative research aimed at understanding the role of molecular mechanisms of neurological diseases.
• Focus on single cell genomics, in combination with induced pluripotent stem cells (iPSCs) and organoids.
• Collaborate with biologists at the Buck Institute for developing standardized protocols and experimental design.
• Use mice to understand neurological disease.
• Perform data analysis, annotation, and report preparation using commercial data integration, pathway analysis and visualization software.
• Attend and participate in institutional programs, seminars, and lectures. 

COMPENSATION & BENEFITS

• The starting salary for a new postdoc at the Buck is $68,000 in 2023, with a range up to $82,000 commensurate with postdoc level & experience.
• Exciting, dynamic work environment at the forefront of science using state-of-the-art techniques.
• Generous benefits package including health insurance, paid parental leave, generous PTO and 401(k) with 5% employer match and profit sharing.
• Collaborative environment – both for science and social activities.