Mitochondria-Lysosome Crosstalk in Aging and Senescence - Zhou, Hansen, and Andersen Labs  

POSITION SUMMARY The Zhou, Hansen, and Andersen Labs at the Buck Institute for Research on Aging are jointly seeking a highly motivated Postdoctoral Researcher to explore the molecular mechanisms of mitochondria–lysosome crosstalk in aging and cellular senescence. This collaborative project spans multiple model systems from cellular models to multicellular organisms such as C. elegans to address how organelle dysfunction contributes to aging and age-related diseases. Mitochondrial dysfunction and lysosomal impairment are conserved hallmarks of aging and central drivers in neurodegenerative diseases, such as Alzheimer’s. This position offers a unique opportunity to work at the interface of cell biology, aging research, and systems-level analysis, using a wide range of cutting-edge technologies:

• Genetic screening and molecular biology
• Super-resolution and cryo-electron microscopy
• High-throughput screening
• Quantitative image analysis and machine learning

The postdoctoral researcher will be co-mentored by three PIs, with Dr. Zhou serving as the primary mentor, and will actively collaborate across labs to conduct cross-species, cross-disciplinary aging research. We welcome candidates who are curious, ambitious, and eager to uncover fundamental biological principles with translational relevance to age-related diseases.

WE OFFER 

• A highly collaborative, innovative environment for aging research in the San Francisco Bay Area
• $71,845 - $80,000 postdoc salary range (commensurate with level & experience)
• Generous benefits package includes health insurance, paid parental leave, vacation/sick leave, and 401(k) with a 5% employer match and student loan repayment option