We are looking for an outstanding biologist who is proactive, independent and collaborative. Our multidisciplinary group works closely with the laboratory of Boris Bastian and focuses on defining histopathologic and genomic subsets of melanoma and understanding their biology. The R01 funded project will focus on the role of NF1 and SPRED1 in melanoma.
The fellow will lead key aspects of the project including continued development and phenotyping of mouse models of NF1 or SPRED1 inactivated melanoma, experiments to interrogate the function of the complex, and screens to identify therapeutic strategies. The postdoctoral research opportunity will expose the fellow to translational work developing patient derived xenografts in collaboration with the melanoma oncology group as well as cancer genetics and bioinformatics.
Responsibilities:
- Oversee the development and evaluation of a mouse model of KIT mutant melanoma.
- Design functional experiments to understand the KIT/SPRED1/NF1 complex and its regulation
- Determine response of patient derived xenografts and cell lines to targeted therapies and perform drug screens.
Requirements:
- Experience with mouse husbandry
- Molecular biology and cell culture experience.
- Strong attention to detail and solid analytical skills.
- Excellent oral and written communication skills.
- Documented track record of scientific achievement.
Preferred:
- Experience with mouse models of tumorigenesis and histopathology.
Education:
- PhD in cancer biology, biomedical sciences, genomics, or a related field.
Interested candidates please contact: Iwei Yeh, MD PhD --> [email protected]