The Solomon Laboratory at UCSF (https://solomonlab.ucsf.edu) is seeking highly motivated postdoctoral research fellows to lead NIH-funded studies examining the role of the cohesin complex in cancer pathogenesis and other translational research projects aimed at deciphering the molecular mechanisms by which novel genetic discoveries in human tumors drive oncogenesis.  Specific projects focus on the mechanisms by the cohesin subunit STAG2 controls replication fork procession and DNA repair, as well as studying the mechanisms by which STAG2 controls mammalian development using a newly developed conditional knockout mouse.  Another ongoing study is examining the role of the TRAF7 gene in the pathogenesis of mesothelioma and meningiomas, tumors in which mutations in this ubiquitin ligase gene are frequent.  We are fundamentally interested in understanding why certain oncogenes and tumor suppressor genes are altered in specific tumor types to drive oncogenesis (for example, why STAG2 mutations are common in glioblastoma, urothelial carcinoma, and Ewing sarcoma but not renal cell carcinoma or osteosarcoma).

Enthusiastic and self-motivated candidates are encouraged to apply. The successful candidate(s) will have a range of opportunities to pursue translational patient-oriented cancer research, with structured mentoring support and opportunities for travel and presentation at national meetings.  Additional professional development opportunities are available through our affiliation with the UCSF Helen Diller Family Comprehensive Cancer Center (http://cancer.ucsf.edu/), the UCSF Department of Pathology (http://pathology.ucsf.edu/), the UCSF Clinical Cancer Genomics Laboratory (https://gmi.ucsf.edu/), and the UCSF Biomedical Sciences Graduate Program (https://bms.ucsf.edu/).