POSITION SUMMARY

Eye Aging and neurodegeneration using flies and mammals

The focus of the Kapahi Laboratory is to identify and characterize the mechanisms by which nutrients modulate aging and age-related diseases. This is being achieved by using an interdisciplinary approach combining genetic, pharmacological, biochemical, and genomic approaches in invertebrate model systems C. elegans, D. melanogaster, and mammalian cells. The broader significance of this research is to help uncover the role of nutrition in the etiology of age-related human diseases like diabetes, obesity, and neurodegeneration. You will join a highly collaborative group and the ability to be a collaborative team member is a key expectation. The position is ideal for candidates who want to transition to academia and write a K99. Strong mentorship and support to write grants will be provided.

Two Postdoctoral positions involve using bioinformatic approaches from flies and humans to study the role of circadian clocks and nutrient-responsive pathways that influence eye and neuronal degeneration using flies and conserved orthologs from humans.

Publications

1. Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock. Sara Ahadi, Kenneth A Wilson Jr, Boris Babenko, Cory Y McLean, Drew Bryant, Orion Pritchard, Ajay Kumar, Enrique M Carrera, Ricardo Lamy, Jay M Stewart, Avinash Varadarajan, Marc Berndl, Pankaj Kapahi, Ali Bashir. Elife. 2023 Mar 28; https://elifesciences.org/articles/82364

1. Dietary restriction and clock delay eye aging to extend lifespan in melanogaster. Hodge BA, Meyerhof GT, Katewa SD, Lian T, Lau C ,Bar S, Leung NY, Li M, Li-Kroeger D, Melov S, Schilling B, Montell C, Kapahi P. Nat Commun. 2022 Jun 7. https://www.nature.com/articles/s41467-022-30975-4

COMPENSATION & BENEFITS

• The starting salary for a new postdoc at the Buck is $68,000 in 2023, with a range up to $82,000 commensurate with postdoc level & experience.
• Exciting, dynamic work environment at the forefront of science using state-of-the-art techniques.
• Generous benefits package including health insurance, paid parental leave, childcare assistance, generous vacation/sick leave, and 401(k) with 5% employer match.
• Collaborative environment both for science and social activities.